Enhanced anti-biofilm and anti-protein adsorption properties of liquid-infused silver-polytetrafluoroethylene coatings

In this work, a slippery liquid-infused silver-polytetrafluoroethylene (AgFP) coating was fabricated via spontaneous polycondensation of 1H,1H,2H,2H-perfluorooctyltriethoxysilane (PFOTES) onto an electroless AgF sublayer. The AgFP demonstrated great stability and superior repellence against liquids with wide range surface tensions. anti-biofouling properties were investigated by adsorption Escherichia coli, Staphylococcus aureus, fibrinogen, bovine serum albumin. Owing to the self-cleaning property, enhanced anti-adhesion activity both bacteria proteins relative traditional coatings, despite fibrinogen deposition significantly promoting bacterial binding. While its ultra-low energy not within optimum region for minimum or protein adhesion, still displayed excellent anti-biofilm capability in protein-bacteria co-deposition model, reducing over 80% BSA-supplemented biomass coverage on Ag surfaces 60% Fgn-supplemented surfaces, respectively. To understand mechanism, XDLVO model used explain adhesion behaviour proteins. Cytotoxicity assays confirmed that had good biocompatibility fibroblast cells. results from research provide attractive prospects application biomedical devices combat infections.